We understand that aging is more than skin-deep. The visible signs, fine lines, dullness, and loss of firmness, are surface reflections of what’s happening on a cellular level. NAD+ (nicotinamide adenine dinucleotide) has emerged as one of the most compelling discoveries in regenerative medicine, with its ability to revitalize the skin by supporting the body’s natural repair processes from within.
Think of NAD+ as cellular fuel. It’s a coenzyme found in every cell of the body, and it’s essential for energy production, DNA repair, and maintaining overall skin integrity. As levels decline over time, so does the skin’s ability to renew itself, retain moisture, and resist environmental stress. That’s where NAD+ IV therapy at House22 becomes a powerful ally in graceful aging, designed not to mask signs of aging, but to help restore radiance from the inside out.
What Is NAD+ and Why Does It Matter
NAD+ plays a fundamental role in cellular health. It facilitates a wide range of enzymatic reactions, including those responsible for converting nutrients into energy, repairing damaged DNA, and activating proteins known as sirtuins, which regulate inflammation and support longevity.
When NAD+ is abundant, skin cells have the energy required to perform at their best, producing collagen, defending against oxidative stress, and maintaining a smooth, hydrated surface. But as early as our thirties, levels of NAD+ begin to decline, impacting the skin’s ability to renew and repair. This depletion contributes to visible signs of aging, including a slower turnover of skin cells and weakened elasticity.
By replenishing NAD+ through medically guided IV infusion, patients can support the skin’s foundational health and cellular vitality. At House22, NAD+ therapy is part of a broader approach to regenerative aesthetics, where science, wellness, and elegance meet.
Why NAD+ Declines, and What That Means for Your Skin
Environmental stressors like sun exposure, lack of sleep, and high cortisol levels accelerate the depletion of NAD+, but the most significant factor is time. Natural aging steadily reduces the body’s production of this vital coenzyme. By midlife, levels may be less than half of what they were in youth.
As NAD+ declines, the body becomes less efficient at producing collagen and repairing DNA. This cellular fatigue can manifest in the skin as dullness, rough texture, dehydration, and early laxity. Over time, the skin loses its ability to bounce back, showing deeper lines and reduced firmness.
Understanding this process allows us to intervene thoughtfully. At House22, we see NAD+ therapy as a way to support the body’s own capacity to repair, making it a meaningful option for patients who want to slow aging with intention and integrity.
Benefits of NAD+ for Skin Rejuvenation
NAD+ doesn’t treat the skin superficially; it revitalizes it from its source: the cell. Patients who incorporate NAD+ therapy into their aesthetic plan often notice changes that reflect deeper biological renewal, not simply cosmetic refreshment.
Here’s how NAD+ contributes to skin rejuvenation:
- Stimulates collagen and elastin production, improving firmness and elasticity
- Supports DNA repair, reducing the impact of sun damage and environmental stress
- Enhances the skin’s moisture barrier, leading to improved hydration and resilience
- Reduces inflammation and oxidative damage, which can accelerate aging
- Improves skin texture and tone, helping to reveal a healthier, smoother surface
These benefits are amplified when NAD+ is combined with other regenerative treatments such as PRF injections, which target structural support, or Skin Boosters, which deeply hydrate and enhance luminosity.
How NAD+ IV Therapy Works at House22
NAD+ IV infusion delivers the coenzyme directly into the bloodstream, bypassing the digestive system and allowing for maximum cellular absorption. Unlike topical serums or oral supplements, IV therapy ensures that NAD+ reaches the bloodstream quickly, where it can be utilized immediately by the cells that need it most, including those involved in skin repair.
Each treatment at House22 is medically directed and tailored to individual goals. Patients are welcomed into a private, serene environment where the infusion experience is both restorative and elevated. The treatment typically lasts 60 to 90 minutes and can be scheduled as part of a focused rejuvenation plan or integrated into a broader wellness program.
As part of our philosophy of intelligent aging, we often pair NAD+ therapy with Sculptra® or Radiesse® to encourage both structural volume and cellular vitality, supporting not only how the skin looks, but how it functions over time.
NAD+ vs. Other Rejuvenation Treatments: A Cellular-Level Advantage
While many treatments focus on the visible layers of the skin, NAD+ operates at a foundational level, recharging the very cells responsible for regeneration. It’s not about choosing NAD+ instead of other treatments, but understanding how it works alongside them for compounded benefits.
At House22, we often recommend combining NAD+ IV therapy with modalities that target different layers of the aging process. For example:
- NAD+ and PRF Injections: While PRF stimulates localized collagen production through growth factors, NAD+ enhances the energy capacity of skin cells, supporting long-term tissue regeneration.
- NAD+ and Skin Boosters: Skin Boosters offer hydration and elasticity on the surface; NAD+ enhances the internal function of the cells, producing hyaluronic acid and maintaining skin health.
- NAD+ and Collagen Stimulators: Injectables like Sculptra® and Radiesse® are biostimulatory fillers that provide structural volume. NAD+ supports the biological environment needed to maintain that result over time.
This synergistic, regenerative layering is what sets House22 apart; treatments are never one-size-fits-all, and true skin vitality is approached from multiple intelligent angles.
Who Benefits from NAD+ IV Therapy?
NAD+ therapy is ideal for those who want to support graceful aging with science-backed strategies that go beyond the surface. It’s also deeply relevant for individuals experiencing skin changes related to stress, fatigue, or metabolic shifts.
Common patient goals include:
- Supporting collagen production without relying solely on fillers
- Restoring energy and vitality during or after demanding life stages
- Enhancing skin tone, firmness, and texture
- Addressing dullness or lack of hydration
- Integrating cellular therapy into weight loss, hormone, or wellness programs
For patients on semaglutide or tirzepatide protocols, NAD+ therapy can also support metabolic function and energy levels. It’s an excellent complement to House22’s medical weight loss programs, helping the skin adapt more effectively to body changes while promoting clarity and cellular rejuvenation.
Patient Experience: What to Expect at House22
Your first NAD+ consultation begins with a physician-led evaluation of your health, goals, and skin history. We assess more than symptoms; we consider how your lifestyle, energy, and cellular function intersect to affect your skin’s appearance and longevity.
Infusions are administered in a private, luxury treatment room. Most patients report a calming sensation during the drip, and some describe a subtle mental clarity or renewed physical energy afterward. A full course typically includes a series of treatments tailored to your needs, with maintenance infusions available seasonally or alongside other skin therapies.
At House22, every detail is considered, down to how NAD+ integrates into your broader care plan. Whether you’re preparing for a skin resurfacing series or recovering from stress-related fatigue, NAD+ serves as a supportive foundation for long-term skin health.
Why Choose House22 for NAD+ in Chicago’s Gold Coast
NAD+ therapy is not new, but how it’s delivered and how it’s integrated into your overall aesthetic and wellness journey makes all the difference.
At House22, our protocols are:
- Medically guided with advanced oversight
- Tailored to your skin and cellular profile
- Designed to pair with regenerative treatments like PRF, exosomes, and dermal biostimulators
- Delivered in a serene, upscale setting in the heart of Chicago’s Gold Coast
We don’t follow trends; we follow the science of cellular renewal and make it accessible through thoughtful, elegant care. For those looking to support their skin with integrity, NAD+ therapy offers something rare: true rejuvenation from within.
Explore what NAD+ therapy could unlock in your skin. We invite you to schedule a consultation and discover the regenerative path that fits your goals.
Frequently Asked Questions
What does NAD+ do for your skin?
NAD+ enhances skin cell energy, promotes collagen production, supports DNA repair, and reduces oxidative stress. The result is improved firmness, tone, and overall vitality.
How is NAD+ administered?
At House22, NAD+ is delivered via IV infusion under medical supervision. This method ensures direct absorption and maximum benefit for skin and overall wellness.
Can NAD+ be combined with other treatments?
Yes. NAD+ is often paired with PRF, Skin Boosters, or Sculptra® to support both structural and cellular rejuvenation.
Who is a candidate for NAD+ therapy?
Adults seeking anti-aging benefits, increased energy, or recovery from fatigue or stress. It’s also ideal for patients managing metabolic changes or undergoing regenerative aesthetic treatments.
How many sessions are needed?
Most patients begin with a foundational series of 4–6 infusions, with frequency based on individual health and skin goals.